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Giri SN, Misra HP, Chandler DB, Chen ZL

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While the FDA is a major benchmark, other major regulatory bodies, such as the European Medicines Agency (EMA) and Health Canada, have their own classifications and processes that determine a compounds legality and status within their jurisdictions

The ergothioneine group showed significantly greater improvements across every measured parameter: melanin index reduction, erythema reduction, skin glossiness, elasticity across three metrics (R2, R5, and R7), spot count, and wrinkle count, all with p values under 0.01