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Aromatase P450 catalyzes the conversion of the C19 steroids-- androstenedione, testosterone, and 16- - hydroxyandrostenedione-- to estrone, estradiol-17 and estriol

The FSP1 inhibitor iFSP1 can also induce ferroptosis or sensitize cells to other ferroptotic inducers [46]

Chronic metabolic stress induces beta cells to adopt a senescence-associated secretory phenotype (SASP), characterised by cytokines and ECM remodelling factors, that spreads into the surrounding environment promoting beta cell failure [57]

Novel drugs that target the metabolic reprogramming in renal cell cancer

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