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Williamson RD, McCarthy FP, Manna S, et al
Laccase activity tests and laccase inhibitors
In murine models of cachexia, ketogenic feeding preserved lean mass and extended survival, an outcome attributed to reduced systemic IL-6 and TNF- as well as direct effects of ketone bodies (primarily -hydroxybutyrate) on muscle proteolysis 376,377,378
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Recombinant IGFBP 4 , capable of IGF-1 binding and resistant to protease cleavage by pregnancy-associated plasma protein-A (PAPP-A), has been shown to block mammary tumor growth and inhibit angiogenesis in a murine BrCa model [69]
