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Milder than GLP-1 agonists but fewer side effects

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The expression of NRF1 is highest in skeletal muscle which is also the tissue that accounts for the largest percentage of glucose disposal in the body and, therefore, is the tissue that is most responsible for the hyperglycemia resulting from impaired insulin signaling

cDNA was diluted to 5 ng/l, and gene expression was measured with quantitative RT-PCR using the KAPA Sybr Fast kit (Roche, SFUKB) on a 384-well format Viia 7 machine (Applied Biosystems)