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People who focus intently on the needle report more discomfort than those who minimize their attention to it
Matsui H, Yamasaki M, Nakata K, Amano K, Nakamura H (2011) Expression of MMP-8 and MMP-13 in the development of periradicular lesions: MMP-8 and MMP-13 in periradicular lesion

Most patients benefit from weekly or biweekly injections, depending on their specific needs and wellness goals
Larger doses do not make up for missed days