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[1] Don't purchase over-the-counter B12 supplements without medical guidance, as this can interfere with accurate assessment and may mask underlying conditions

Its a two-way street in IBD, with the gut microbiome changes potentially causing high homocysteine, but then high homocysteine will increase the inflammation in the gut.[ref] Gastrointestinal production of homocysteine: Gut microbes that produce folate: The amount of folate produced by the gut microbiome is on a similar scale to what we get from food, so it is a significant source of folate for most people

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Crystal structure of the alkylated human enzyme

Oxford Open Immunol