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The therapy as a shared effect, noted in the severe ischemia condition, as well as in advanced reperfusion, consistently and rapidly counteracts occlusion/occlusion-like syndrome as a whole, restoring function by effectively bypassing loops of minor vessels (e.g., direct blood flow [129,130,131,132,133,134,135,136,137,138,139,140,141,142,168] via the azygos vein) to counteract the failure of major vessels [129,130,131,132,133,134,135,136,137,138,139,140,141,142,168]