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C/EBP has been shown to regulate cell survival in response to DNA damage, toxicants, or oncogenic stress, and knockdown of C/EBP in certain cancer cells results in cell apoptosis (Buck et al., 2001
Overall, the elevation in acyl-carnitines in CESLAC patients appear to not be due to enzymatic defects but rather due to a functional abnormality related to altered metabolism

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These results further corroborate that chronic clenbuterol treatment triggers a shift in SKM of preferential energy substrates from lipids to glucose, in agreement with the transcriptomic, metabolomic, and isotope labeling data (see above)

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