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T2DM develops due to insulins inhibitory effect on liver glucose production or due to different defects in insulin secretion

Patients with pernicious anemia have a higher incidence of stomach carcinoma, so appropriate tests should be performed when indicated

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In male patients with KRAS-mutant CRC, decreased ferritin activity has also been observed, suggesting that these tumors may depend on mitochondrial redox-buffering mechanisms to evade iron-dependent cytotoxic responses [5, 72, 73]