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While AgRP GHR KO mice showed no changes in growth or basal metabolism, both LepR GHR KO and brain GHR KO mice displayed increased weight gain over time, associated with a higher body length

doi: 10.1002/gepi.21965 40

In the methionine choline-deficient (MCD) diet-fed NASH model, the primary role of caspase-8 is to prevent excessive activation of necroptosis and caspase-8-deficient mice develop large amounts of RIPK3 in hepatocytes, leading to severe liver injury and fibrosis

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These toxicities may be due to kratom/mitragynine, but the blood concentrations of mitragynine varied considerably (0.020.18 g/g)