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Anaphylactic shock and death have been reported after parenteral vitamin B 12 administration

British Journal of haematology

B12 shots contain about 100 micrograms of B12, which is roughly 40 times the recommended daily value for an average healthy adult (2.4 micrograms)
ATM-deficient mice, worms, and cell models demonstrated accumulation of cytoplasmic DNA, hyperactivation of PARP1, and low NAD + levels 111,288

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