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While iron and transferrin have been shown to induce hepatic stellate cell activation and collagen expression in vitro [86,87,88], in vivo models of iron overload demonstrate only minor fibrosis, although the numbers of alpha-smooth muscle actin (SMA)-positive myofibroblasts were significantly increased [89, 90]

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For a few years, a loophole in compounding rules had allowed specialty pharmacies to make and market these peptides

On the other hand, corepressors suppress gene expression by recruiting histone deacetylases (HDACs) to deacetylate histones, leading to chromatin compaction [148, 149]

M., Kelly D