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It would depend on various factors and would vary greatly between individuals

2.5 Histological assessment of IENF density The sensory disturbance observed in CIPN patients is often associated with the loss of sensory nerve fibers, as reflected by a prominent reduction in intraepidermal nerve fibers (IENFs) in skin biopsies and mouse model of CIPN (Siau et al., 2006

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In focal ischemia, the damaging action of oxidative stress in necrosis and apoptosis has been explained in previous studies [160, 161]

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