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Specifically, we identified KU-57788 as a DRP1 agonist that induces excessive mitochondrial fission, which in turn activates the NRF2/SLC7A11/GSH axis as a protective response in ATC cells to mitigate its cytotoxic effects

MEK1/2 inhibitors suppress pathological -synuclein and neurotoxicity in cell models and a humanized mouse model of parkinson's disease

Accordingly, phytochemicals present in plant-based diets can provide significant benefits in diabetes management by enhancing insulin sensitivity, reducing oxidative stress, and regulating blood sugar levels through modulating numerous antidiabetic actions, making them a promising natural adjunct to traditional therapies for improving metabolic health

[DOI] [PMC free article] [PubMed] [Google Scholar] 637.Attar, A

& Raphael, W