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These losses lead to impaired axonal function, increased vulnerability of axons to damage, and result in significant brain atrophy and neuro-axonal degeneration

Although Nrf2 does not directly contribute to aerobic glycolysis, glucose uptake and glycolytic activity are stimulated under the sustained activation of the PI3KAkt signaling (Wieman et al., 2007), thereby increasing the supply of glycolytic intermediates

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