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Studies in human TfR knockin (TfRmu/hu KI) mice and nonhuman primates (NHPs) confirmed the broad distribution of therapeutic ASOs across brain regions, highlighting the OTVs potential for treating AD [121]
Younus F, Chertemps T, Pearce SL, Pandey G, Bozzolan F, Coppin CW
doi: 10.1177/1087054719829816
Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants
[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Arauz J., Zarco N., Segovia J., Shibayama M., Tsutsumi V., Muriel P
