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Studies showed that activation of the mTOR pathway has been identified in benign and malignant NF1 tumors [247, 248], suggesting that activation of autophagy by inhibiting mTOR pathway could be a potential therapeutic strategy for optic neuropathy in patients with glioblastoma

Takeda et al., 2013)

It tends to look like reduced resilience across the board: slower recovery, less bandwidth, a body working harder to maintain the same ground

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Results Preclinical Assessment of Immunogenic Risk for AMG 966 In order to assess the immunogenic risk of AMG 966 and the charge pair mutations ( Supplementary Figure 1 ), an in silico analysis of MHC class II binding was performed using the Immune Epitope Database (IEDB) tool