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The medication also carries warnings involving pancreatitis, diabetic retinopathy complications, acute kidney injury due to volume depletion, severe gastrointestinal adverse reactions, gallbladder disease, and other safety considerations

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RhlI and RhlR are primarily responsible for the synthesis and detection of N-butanoyl-L-homoserine lactone (C4-HSL), which also promotes the transcription of RhlI, which in turn promotes the expression of virulence factors [79]