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3 A portion of this guideline is derived from research and consensus-based processes, but IC diagnosis is based primarily on clinical principles and expert opinions
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Underlying allergic conditions, such as atopic dermatitis or cutaneous adverse food reactions, are often the primary cause of otitis, with secondary bacterial otitis as the complicating perpetuating factor [177,179]

Ascorbate may also play a key role in policing organelle to nucleus communication and signalling pathways

Eur J Immunol (2009) 39:160818