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doi: 10.9758/cpn.2017.15.3.229 144 PavalD

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Irradiated tumor cellderived microparticles mediate tumor eradication via cell killing and immune reprogramming

Nitrogen mustard, a known lung-targeting vesicular agent, can cause acute injury and fibrosis, and activated macrophages have been demonstrated to contribute to the pathological response to nitrogen mustard

Treatment of SOD1 G93A mice found that this compound improved the neurological phenotype of the animals, as assessed by motor performance tests, decreased spinal cord pathology, delayed the time to symptom onset, and improved survival in a dose-dependent manner (Hilton et al., 2017