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It has been proposed, among other theories, that an abnormal placentation may induce an endothelial dysfunction, which is ultimately responsible for the final clinical manifestations
Front Neurol (2012) 3:160.10.3389/fneur.2012.00160 10 BergTJensenJ

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury
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Post-translational modifications have clear impacts on the tumor suppressor function of p53