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Increased permeability of the mitochondrial membrane results in instability of mtDNA, further OXPHOS dysfunction, and disrupted Ca 2+ homeostasis

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Immune system Immune cells including neutrophils, basophils, CD8 + and CD4 + T cells, B cells, NK cells, plasmacytoid DC, classical/intermediate or non-classical monocytes in the blood are observed in rhesus, cynomolgus macaques and humans and have similar surface markers (169, 176)

For instance, HK2, the first rate-limiting enzyme in glycolysis, localizes to the nucleus, where it interacts with chromatin-associated factors such as 53BP1 and RAD51, potentially influencing the DDR [145]

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