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It is well established that overexpression of GRKs or arrestins can profoundly enhance induction of endocytosis by morphine (Whistler and von Zastrow, 1998

Hence, the two chromophores are optically coupled and excitation of either can trigger AdoCbl photoconversion, thereby expanding light sensitivity to cover most of the visible spectrum

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Together, these mechanisms likely contribute more to pelvic pain in PCOS than the structural ovarian features themselves