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This gradient mechanismranging from low-concentration signaling blockade to high-concentration multi-pathway synergyexhibits concentration-dependent anti-inflammatory activity in LPS-stimulated HaCaT keratinocytes (1.520 M), with no cytotoxicity observed below 6 M (Nguyen et al., 2022)
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Clinically significant mainly in severe deficiency cases
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Scavenger receptor class B, type I: a promising immunotherapy target
