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Heavy grazing was simulated by toping the blade and light grazing was simulated by 2 holes punched through the blade with a hole puncher

Nature Aging 2021;1, 1117-1126, doi:10.1038/s43587-021-00151-2
Llull L, Laredo C, Ren A, et al
Key Triggers for Candida Die-Off Die-off can be sparked by one change or a combination

Well, a few examples would be poor hydration, even down to consuming foods that don't have a lot of water in them, like ultra processed packaged foods out of crinkly containers