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Pyruvate can, in turn, be transformed to Lactate, restoring NAD + needed for anaerobic glycolysis and production of ATP (Figure 1B)

10.1016/j.ijbiomac.2023.126038 17 ChenS.-K.WangX.GuoY.-Q.SongX

376 The particle core of Cas9/sgRNA complexes were decorated with positively charged polymer via electrostatic interactions, as the particle size increased from 17 nm for naked Cas9/sgRNA to 31 nm

doi: 10.1111/acel.12219 90 HoongCWSChuaMWJ

The way Irina explained it to me is that the age of the biological of the body is simply a measure of how much damage has accumulated, but that cycles of epigenetics and catalysis are self-reinforcing