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Endogenous tissue inhibitors of MMPs (TIMPs) play a crucial role in safeguarding the BBB from disruption after ischemia by regulating the activities of MMPs [198]

Mechanistic studies suggest that certain natural products and isolated compounds can enhance lipid metabolism and reduce inflammation and fibrosis through pathways including PPAR/INSIG/SREBP1c and the transforming growth factor- (TGF-)/Smad/mitogen-activated protein kinase (MAPK) signaling pathway (Wu et al., 2019)

Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglianeuron interaction

The nervous system rapidly regulates organ interactions through pathways such as the vagus nerve, 17,18 whereas the endocrine system transmits information across multiple organs via hormonal signals such as insulin and cortisol