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All combination data comes from anecdotal clinical observations or theoretical synergy based on separate mechanisms

tells the Mayo Clinic, Low levels of B-12 and other B vitamins such as vitamin B-6 and folate may be linked to depression. Studies may be inconclusive, but at the very least, a holistic and integrated approach to ones health in the form of adequate vitamins and nutrients helps achieve a more balanced biology that certainly wont hurt your overall mood

Vitamin B12, folic acid and the nervous system

It can be hard, but there is hope

No human efficacy trial has met the evidentiary bar for regulatory approval