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Elucidation of the mechanistic basis of such synergistic effects could enable the design of rational combination regimens that use lower doses of cytotoxic drugs with fewer side effects and overcome multidrug resistance (Musso and Biscussi, 2025)

Among these genes, the expression of CP increased in astrocytes, the expression of HMGB1 increased in all types of cells, and the expression of TF decreased in oligodendrocytes (Table 2)

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Haematological toxicity of valproic acid compared to levetiracetam in patients with glioblastoma multiforme undergoing concomitant radio-chemotherapy: a retrospective cohort study