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Additionally, suPAR, a marker of chronic inflammation and immune senescence that has been previously implicated in acute COVID-19 severity (87), was the only plasma biomarker that was significantly elevated in LC compared to recovered individuals

Whereas, activation of LKB1AMPK signaling might contribute to the suppression of cancer risk and, thus, pharmacological modulators, such as TQ, which was shown to activate LKB1AMPK signaling [106], could have therapeutic promise in cancer prevention

All cells except HepG2 were maintained in RPMI 1640 media (Gibco) containing 2mM glutamine, 10% fetal bovine serum, 1% penicillin and streptomycin

The purine component in NAD + is adenine, which is incorporated from ATP 23