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Lipners slides referenced a 2002 cohort study performed by Ronger and colleagues evaluating 148 consecutive cases of LM over a 4-year period in an outpatient clinic 12

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The ubiquitous vitamin B 12 -dependent methionine synthase (MS) enzyme also catalyzes the re-methylation of homocysteine, using the folate derivative, 5-methyltetrahydrofolate, as a methyl donor (see Nutrient interactions)

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