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But Increased GH and IGF-1 Are Not a Free Upgrade Endocrine changes at this scale come with potential trade-offs: Fluid retention Glucose regulation concerns Possible long-term diseases questions linked to IGF-1 elevation (Holt, 2025

Risks vary by peptide, dose, and individual health context

Protein-based hybrid responsive microparticles for wound healing

Most available data are preclinical or derived from non-orthopaedic clinical contexts, and robust human orthopaedic trials were not identified
