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A randomized trial comparing the dorzolamide-timolol combination given twice daily to monotherapy with timolol and dorzolamide

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Zangari M, Aujay M, Zhan F, Hetherington KL, Berno T, Vij R, Jagannath S, Siegel D, Keith Stewart A, Wang M , Orlowski RZ, Belch A, Jakubowiak A, Somlo G, Trudel S, Bahlis N, Lonial S, Singhal S, Kukreti V, Tricot G

Their antidepressant effects are mainly accomplished by inhibiting monoamine oxidase activity, scavenging free radicals, and preventing lipid peroxidation (Sun Y, 2014)
