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There is around a 2.5-fold increase in B12 deficiency incidence in those treated with metformin, and this may occur as early as 3 months, although hepatic stores of vitamin B12 may take 5 years or more to deplete (Bell, 2022)

Compounded GLP-1 injection Compounded GLP-1 is a customized weight management treatment that combines with Vitamin B12 to support appetite control, blood sugar regulation, and energy levels

Additionally, Metformin may alter gut bacteria, potentially leading to intestinal bacterial overgrowth that further hinders B12 uptake

The FDA has specifically warned consumers against HCG products marketed for weight loss

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