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It is noteworthy that NRF2 regulates the expression of enzymes necessary to synthesize GSH, including glutamate-cysteine ligase catalytic subunit (GCLC) and its regulatory subunit (GCLM), glutathione reductase (GR), glutathione peroxidase (GPx), and several glutathione S-transferases (GST) (Suh et al
Accessed 12/3/20, Haress NG
400,401 Coupled with its role in regulating cell proliferation, AKT signaling is involved in regulating glucose homeostasis and lipid metabolism
