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Genetically modified folate overproducing strains of some fungi and bacteria have been constructed, e.g., Ashbya gossypii , Escherichia coli , and Bacillus subtilis , the first being the best folate producer reported to date with folate titers of 6.6 mg/L (i.e., 146-fold higher than the wild strain) 631,632,633,634

doi:10.5152/npa.2016.18143 Wei W, Sayyid ZN, Ma X, Wang T, Dong Y

doi: 10.1038/s12276-017-0005-x 111 CortelazzoADe FeliceCGuyJTimperioAMZollaLGuerrantiRet al

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