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Of the 34 patients with Hunner lesions, although 29/34 (85%) had a successful response, six of these patients stopped the medication for AEs, leaving a final success rate of 68% (23/34)

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Sanz AB, Sanchez-Nio MD, Ramos AM, Moreno JA, Santamaria B, Ruiz-Ortega M, et al

Because administration of desmopressin acetate can been associated with decreased responsiveness with prolonged use, consider increasing the dosage of DDAVP Nasal Spray if patients demonstrate decreased response over a long period of time

Long-term remodeling (weeks 2-8+) shows improved collagen maturation and tissue strengthening