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Intercellular junctions, such as tight junction, adherent junction, and desmosomes, have a key role in the paracellular passage (Figure 1)

Among these, the activation of the FAK-paxillin signaling cascade is among the most impressive, as it is responsible for cell adhesion, migration, and proliferation

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These symptoms may suggest inadequate B12 replacement, concurrent iron or folate deficiency, or alternative haematological conditions requiring investigation