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Figure 2 The neurodegenerative effect mediated by AngII and the AngII-AT 1 R complex are mediated by an increased release of ROS via the NADPH-oxidase complex in microglia and dopaminergic neurons, resulting in a vicious proinflammatory circle (123)

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Instead, participants may be assigned to either receive standard of care (the treatment currently available) or the new treatment to see which is more effective