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, Gallaher, C

Insomnia is categorized as: Sleep onset insomnia , which makes it difficult to get to sleep at a reasonable time

Folinic acid (2 mg/kg/day, max 50 mg/day) produced significantly greater improvements in standardized verbal communication scores and several adaptive and behavioral subscales compared with placebo, with a stronger effect on children (Frye et al., 2018)
This delay is not due to ER-mitochondria Ca 2+ signaling, as NMDA-induced RyR-dependent Ca 2+ release is similar in both genotypes

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