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Both compounds are likely to require indefinite administration to sustain weight loss discontinuation studies with GLP-1 agonists (a similar class to cagrilintide mechanistically) show two-thirds of lost weight returns within 12 months of stopping

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Zebrafish genes 87% homology with human genes, and their biological structures and physiological functions are highly similar to those of mammals 18

For AD-GTPCHD, there is certain heterogeneity: Some publications discuss and exclude genotype-phenotype correlation [35, 36]