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In a subsequent compassionate use study, Kinostat maintained the dogs vision for up to 8 years

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CB-1158 could block myeloid cell-mediated inhibition of T cell proliferation, increase the number of tumor-infiltrating CD8 + T cells and NK cells, and increase the expression of inflammatory factors and interferon-, thereby changing the immune microenvironment to promote inflammation and reduce tumor immune escape, inhibiting tumor cell proliferation

The green dashed line indicates the temperate japonica genotype of CHPO