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Description
JAMA dermatol

Various medications used to treat ulcerative colitis will target specific parts of the immune system, stopping the inflammatory response responsible for UC symptoms

Upon binding to its receptor on TFH cells, the cytokine IL-21 upregulates the expression of BCL-6, CXCR5, and ICOS through the janus kinase (JAK)- signal transducer and activator of transcription (STAT) axis, indirectly promoting the migration of TFH cells and the production of pathogenic antibodies (139)

Inflammation and proliferation act together to mediate intestinal cell fusion

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