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When the researchers treated mice with a peptide that blocks the hyperactive version of an enzyme called CDK5, they found dramatic reductions in neurodegeneration and DNA damage in the brain

VEGF is induced using multiple classes of antidepressants at time points consistent with the induction of cell proliferation and therapeutic action of these treatments [297,298]

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The bioavailability difference between routes means the same biological effect requires a higher oral dose than injectable but the mechanistic effects themselves translate across routes because the absorbed fraction reaches systemic circulation intact enough to engage the same downstream pathways