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Thus, tofersen illustrates both the promise of targeted genetic therapy and the current reality that its most significant impact may be on disease biology, with clinical benefits requiring longer timeframes to manifest or being more modest than initially hoped

These guidelines and scores focus on choice of sedation agent, scoring of the level of sedation and timing of sedation hold, but not the process itself
NIH, National Institutes of Health

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Choice D: Focusing immediately on the herbal tea prioritizes a specific detail over the patient's primary reason for the visit