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Synthesis and pharmacological characterization of novel peripheral cannabinoid-1 receptor blockers based on a tricyclic scaffold

6.2.3.2 Myelin vacuolization and demyelination NO-induced Vit B12 inactivation results in MMA accumulation ( 6.2.3.3 Cytokine dysregulation and myelin swelling Elevated levels of proinflammatory cytokines, such as TNF-, and reduced levels of epidermal growth factor have been observed in Vit B12-deficient states ( 6.3 Clinical manifestations of nervous system injury NO-induced injuries are classified into acute, subacute, and chronic phases

6-Month Cycle: Inject 1mL per week of month 1, every other week in month 2, 1 time per month for months 3-6 (10 ML total)

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