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In a multicenter, self-controlled trial conducted in 2017 at the Department of Neurology and Psychiatry, Sapienza University, Italy (N = 82 LOE3A), patients with CTS had a mean age of 47.1 years

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In the biomarker discovery and validation set, the disease group consisted of a mixture of patients exposed and unexposed to drug treatment including antidepressants for the treatment of MDD

34 Notably, ALA is an enantiomer and occurs naturally in its R isoform, yet synthetic ALA is a racemic mixture of the R and S isoforms and the S-ALA has been found to increase bioavailability by preventing polymerization of R-ALA