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Future Perspectives The scientific studies on seleno-GPxs have so far led to the understanding that the physiological role of seleno-GPxs is not only limited to detoxification of peroxides, but also involves regulating signaling pathways (such as chromatin remodulating, NF-B activation, insulin signaling, mitochondrial integrity, and ferroptosis, among others) [1, 8,9,10]

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Additional indicators of nociplastic pain include extensive healthcare utilization, high levels of pain-related distress, and a family history of chronic pain or psychological disorders

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Cancer cells use precursors derived from the TCA cycle intermediates to synthesize proteins, lipids, and nucleic acids