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Ascorbic acid reacts with a variety of ROS and redox-active transition metals (Fig

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Niclosamide has been found to provide a protective effect by blocking glutaminolysis and the Wnt/-catenin signaling pathway linked to liver fibrosis ( Concerning the role of Wnt signaling dysregulation in renal impairment, it has been reported that renal fibrosis can be alleviated, and kidney function can be enhanced by blocking the Wnt/-catenin pathway

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18 The different biological activities induced by the components of SASP suggest that it may interact with local and surrounding cells, and constitutes a mechanism to regulate microenvironment, which could be either beneficial or deleterious, depending on the secretion factors, site (cell types), duration (acute or chronic), and secretion-induced stimuli

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Novel approaches utilising red-shifted dyes to reduce autofluorescence and to allow multiplexing of samples are also emerging

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