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In hepatocellular carcinoma (HCC) studies, ADI-PEG-20 has been shown in early clinical trials to make HCC animal models and patients more sensitive to FOLFOX chemotherapy through arginine depletion
Xi H, Kurtoglu M, Lampidis TJ

120150 min: n = 12

Iron homeostasis imbalance and ferroptosis in brain diseases

Impaired secretion of reproductive hormones at the hypothalamus and pituitary levels following MSG administration would compromise testosterone secretion and consequently negatively impact the process of spermatogenesis (Hamza and Al-Harbi, 2014, Pakarainen et al., 2005)
